1. 学術論文

2015以降

1) Mori, Y., Akita, K., Yashiro, M., Sawada, T., Hirakawa, K., Murata, T., Nakada, H., Binding of Galectin-3, a β-Galactoside-binding Lectin, to MUC1 Protein Enhances Phosphorylation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) and Akt, Promoting Tumor Cell Malignancy. J. Biol. Chem., 290, 26125-26140 (2015).

2) Y. Watanabe, Y. Arai, T. Daidoji, N. Kawashita, M. Ibrahim, E. El-Din El-Gendy, H.i Hiramatsu, R. Kubota-Koketsu, T. Takagi, T. Murata, K. Takahashi, Y. Okuno, T. Nakaya, Y. Suzuki, and K. Ikuta: Characterization of H5N1 Influenza Virus Variants with Hemagglutinin Mutations Isolated from Patients. mBio, 6, e00081-15 (2015).

2010-2014

1) Usida, K. and Murata, T: Material science and engineering of mucin. A new aspect of mucin chemistry, Studies in Natural Products Chemistry 39, 115-159 (2013).

2) Suzuki, T., Sugiyama, K., Hirai, H., Ito, H., Morita, T., Dohra, H., Murata, T., Usui, T., Tateno, H., Hirabayashi, J., Kobayashi, Y., and Kawagishi, H., Mannose-specific lectin from the mushroom Hygrophorus russula, Glycobiology, 22, 616-629 (2012).

3) Ogata, M., Yano, M., Umemura, S., Murata T., Park, E. Y., Kobayashi, Y., Asai, T., Oku, N., Nakamura, N., Matsuo, I., and Usui, T., Design and synthesis of high-avidity tetravalent glycoclusters as probes for Sambucus sieboldiana agglutinin and characterization of their binding properties. Glycoconjugate. Chem., 23, 97-105, (2012).

4) 戸田 宗豊、村田 健臣、笹野昂太、中田 博：人工グリコポリマーによる癌転移抑制および抗炎症作用、京都産業大学先端科学技術研究所所報、第10号、15-23、(2011).

5) Ohta M., Ishida A., Toda M., Akita K., Inoue M., Yamashita K., Watanabe M., Murata T., Usui T., Nakada H.: Immunomodulation of monocyte-derived dendritic cells through ligation of tumor-produced mucins to Siglec-9. Biochem. Biophys. Res. Commun. 402, 663-669 (2010).

6) Ogata M., Obara T., Chuma Y., Murata T., Enoch Y. Park, and Usui T., Molecular design of fluorescent labeled glycosides as acceptor substrates for sialyltransferases. Biosci. Biotechnol. Biochem. 74, 2287-2292 (2010).

7) Ogata M., Murata T., Park, E-Y. and Usui T , Chemoenzymatic synthesis of glycan-arrayed polymeric inhibitors against influenza infection. J. appl. Glycosci. 57, 137-144 (2010)

8) Masaka, R., Ogata, M., Misawa, Y., Yano, M., Hashimoto, C., Murata, T., Kawagishi, H., and Usui, T., Molecular design of N-linked tetravalent glycosides bearing N-acetylglucosamine, N,N'-diacetylchitobiose and N-acetyllactosamine: Analysis of cross-linking activities with WGA and ECA lectins, Bioorg. Med. Chem. 18(2), 621-629 (2010).

9) Horibe, M., Kobayashi, Y., Dohra, H., Morita, T., Murata, T., Usui, T., Nakamura-Tsuruta, S., Kamei, M., Hirabayashi, J., Matsuura, M., Yamada, M., Saikawa, Y., Hashimoto, K., Nakata, M., and Kawagishi, H., Toxic isolectins from the mushroom Boletus venenatus, Phytochemistry, 71, 648?657 (2010).

2005-2009

1) M. Nagae, N. Nishi, T. Murata, T. Usui, T. Nakamura, S. Wakatsuki, and R.Kato: Structural analysis of the recognition mechanism of poly-N-acetyllactosamine by the human galectin-9 N-terminal carbohydrate recognition domain. Glycobiology 19, 112-117 (2009).

2) Adachi T., Sato C., Kishi, Y, Totani, K, Murata,T., Usui, T. and Kitajima, K. Membrane microdomains from early gastrula embryos of medaka,Oryzias latipes , are a platform of E-cadherin- and carbohydrate-mediated cell?cell interactions during epiboly. Glycoconjugate J. 26, 285-299 (2009).

3) Ogata M., Hidari K., Murata T., Shimada S., Kozaki, M. Park, E-Y., Suzuki T. and Usui T.: Chemoenzymatic synthesis of sialyglycopolypeptides as glycomimetic to block infection by a avian and human influenza virus infection. Bioconjugate Chem. 20, 538-549 (2009).

4) Hidari K., Kozaki W., Murata T., Hiratake J., Park, E-Y., Suzuki T. and.: Molecular design of spacer-N-linked sialyglycopolypeptides as polymeric inhibitor against influenza virus infection. Biomacromolecules. 10, 1894-1903 (2009).

5) Usui T., Ogata M., Murata T., Ichikawa K., Sakano Y., and Nakamura Y.; Sequential amalysis of a-glucooligoshaccharides with a-(1-4) and a-(1-6) linkages by Nagative ion Q-TOF MS/MS spectrometry. J. Carbhydr. Chem. 28, 1-10, (2009).

6) K. Hidari, T. Murata, K. Yoshida, Y. Takahashi, Y. Minamijima, Y. Miwa, S. Adachi, M. Ogata, T. Usui, Y. Suzuki and T. Suzuki: Chemoenzymatic synthesis, characterization, and application of glycopolymers carrying lactosamine repeats as entry inhibitors against influenza virus infection. Glycobiology18, 779-788 (2008).

7) Ishida, A., Ohta, M., Toda, M., Murata, T., Usui, T., Akita, K., Inoue, M., Nakada, H. Mucin-induced apoptosis of monocyte-derived dendritic cells during maturation. Proteomics, 8, 3342-3349, (2008).

8) Misawa, Y,, Akimoto, T., Amarure, S., Murata T. and Uusi T: Enzymatic synthesis of spacer-linked divalent glycosides carrying N-acetylglucosamine and N-acetyllacrosamine: Analysis crosse-linked activity with WGA. J. Biochem. 143, 21-30,(2008).

9) Misawa Y., Masaka R., Maeda K., Yano M., Murata T., Kawagishi H. and Usui T.: Efficient synthesis of spacer-N-linked double-headed glycosides carrying N-acetylglucosamine and N,N′-diacetylchitobiose and their cross-linking activities with wheat germ agglutinin. Carbohydr. Res. 343, 434-442 (2008)．

10) Sasanami T.,Murata T., Ohtsuki M., Matsushima K., Hiyama, G. Kansaku N. and Mori M., Induction of Sperm Acrosome Reaction by Perivitelline Membrane Glycoprotein ZP1 in Japanese Quail (Coturnix japonica) Reproduction, 133 (1): 41-49. (2007).

11) Ogata, M., Murata T., Murakami K., Suzuki T., Hidari KI., Suzuki Y., and Uusi T., Chemoenzymatic synthesis of artificial glycopolypeptides containing multivalent sialyloligosaccharides with a γ-polyglutamic acid backbone and their effect for inhibition of infection by influenza viruses. Bioorg. Med. Chem., 15, 1383-1393 (2007).

12) Nari, P., Tokoro, S., Yokoyama, S. Miura T., Murata, T., Nishida, Y., Kajimoto, T., Tsujino, S., Inazu, T., Usui, T., and Mori, H., Monovalent Gb3-/Gb2-Derivatives Conjugated with a Phosphatidyl Residue: A Novel Class of Shiga Toxin-Neutralizing Agent Paola. Biol. Pharm. Bull. 30, 1697-701 (2007).

13) Yamada S., Suzuki Y., Suzuki T., Le MQ., Nidom CA., Sakai-Tgawa Y., Muramoto Y., Ito M., Kiso M., Horimoto T., Shinya K., Sawada T., Kiso M., Usui T., Murata T., Lin Y., Haire LF., Stevens DJ., Russell RJ., Gambin ST., Skehel JJ., and Kawaoka Hemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptor. Nature,444, 378-382 (2006).

14) Murata T. and Usui T.：Enzymatic synthesis of oligosaccharides and neoglycoconjugates., Biosci. Biotechnol. Biochem., 70, 1049-1059 (2006).

15) Nagae M, Nishi N, Murata T, Usui T., Nakamura T., Wakatsuki S., and Kato R., Crystal structure of the galectin-9 N-terminal carbohydrate recognition domain from Mus musculus reveals the basic mechanism of carbohydrate recognition. J. Biol. Chem.,281, 35884-35893 (2006).

16) Tsuruhami, T., Mori, S., Amarume, S., Saruwatari, S., Murata, T., Hiratake, J., Sakata, K., and Usui, T., Isolation and characterization of a s- primeverosidase-like enzyme from Penicillium multicolor. Biosci. Biotechnol. Biochem. 69, 166-178 (2006).

17) Murata,T., Amarume, S., Hattori, T. Tokuyama, S., Tokuyasu, K., Kawagishi, H., and Usui, T.：Purification and characterization of a chitinase from Amycolatopsis orientalis with N-acetyllactosamine-repeating unit releasing activity. Biochem. Biophys. Res. Commun. 336, 514-520 (2005).

18) Murata,T., Honda, H., Hattori, T. and Usui T.：Enzymatic synthesis of poly-N-acetyllactosamines as potential substrated for endo-b-galactosidase-catalyzed hydrolytic and transglycosylation reaction. Biochim. Biophys. Acta.1722, 60-68 (2005).

19) Murata,T., Hattori, T., Honda, H., Amarume, S., and T. Usui：Kinetic studies on endo-b-galactosidase by a novel colorimetric assay and synthesis of poly-N-acetyllactosamines Using its Transglycosylation Activity. J. Appl. Glycosci. 52, 161-168 (2005).

20) Tsuruhami, T., Mori, S., Amarume, S., Saruwatari, S., Murata, T., Hiratake, J., Sakata, K., and Usui, T., Efficient synthesis of b-primeverosides as aroma precursors by b-diglycosidase from Penicillium multicolor. J. Charbohydr. Chem. 24, 849-863 (2005).

21) Kato, T., Suzuiki, M., Murata, T., and Park, E. Y., The effects of N-glycosylation sites and the N-terminal region on the biological function of s1,3N-acetylglucosaminyltransferase 2 and its secretion. Biochem. Biophys. Res. Commun., 329, 699-705 (2005).

22) Kobayashi, Y., Nakamura, H., Sekiguchi, T., Takanami, R., Murata, T., Usui, T. and Kawagishi, H. Analysis of the carbohydrate binding specificity of the mushroom Pleurotus ostreatus lectin by surface plasmon resonance. Anal. Biochem., 336, 87-93 (2005).

23) P Hidari. K., Horie N., Murata T., Miyamoto D. , Suzuki T. , Usui T. and Suzuki Y.urification and characterization of a soluble recombinant human ST6Gal I functionally expressed in Escherichia coli. , 22, Glycoconjugate j. 1-11(2005).

24) Harada, Y., Murata, T., Totani, K., Kajimoto, T., Masum, S. M. Tamba, Y., Yamazaki, M. and Usui T.: Design and facile synthesis of neoglycolipids as lactosylceramide mimetics and their transformation into glycoliposomes. Biosci. Biotechnol. Biochem. 69, 166-178 (2005).

25) Kato, T, Murata, T, Usui, T, and Park, E-Y. Improvement of prodaction of GFPuv- b-1,3-N-acetylglucosaminyltransferaee 2 fusion protein using a molecular chaperon-assisted insect-cell-based expression system. Biotech and Bioeng. 89, 424-433, (2005).

2000-2004

1) Kobasa, D., Takada, A., Shinya, K., Hatta, M., Halfman, P., Theriault, S., Suzuki, H., Nishimura, H., Mitamura, K., Sugaya, N., Usui, T., Murata, T., Maeda, Y., Watanabe, S., Suresh, M., Suzuki, T., Suzuki, Y., Feldmann, H., Kawaoka, Y.: Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus. Nature　431, 703-707 (2004).

2) Kobayashi, Y., K. Kobayashi, Umehara, K., Dohra, H., Murata, T., Usui, T., and Kawagishi, H., Purification, characterization, and sugar binding specificity of an N-glycolylneuraminic acid-specific lectin from the mushroom Chlorophyllum molybdites. J. Biol. Chem. 279, 53048-53055 (2004).

3) Murata, T., Hattori, T., Amarume, S., Koichi, A. and Usui, T. : Kinetic studies on endo-β-galactosidase by a novel colorimetric assay and synthesis of N-acetyllactosamine-repeating oligosaccharide β-glycosides using its transglycosylation activity. Eur. J. Biochem., 270, 1-11 (2003).

4) Zhuang, C., Murata, T., Usui, T., Kawagishi, H. and Kobayashi, K., Purification and characterization of a lectin from the toxic mushroom Amanita pantherina. Biochim. Biophys. Acta, 1291, 40-44 (1996). 1) Totani, K., Shimizu K., Harada Y., Murata T., and Usui T.: Enzymatic synthesis of oligosaccharide comtaining Lex unit using partially purified chicken serum. Biosci, Biotechnol,.Biochem. 66, 636-640 (2002).

5) Kawagishi, H., Takagi, J., Taira, T., Murata, T. and Usui, T., Purification and characterization of a lectin from the mushroom Mycoleptodonoides aitchisonii. Phytochemistry, 56, 53-58 (2001).

6) Kawagishi, H., Yasui, M., Uno, A., Murata, T., Usui, T. and Furukawa, S., Purification and characterization of two lectins from a toxic moray, Gymnothrax javanicus. Biosci. Biotechnol. Biochem., 65(11), 2437-2442 (2001).

7) Murata, T., Kosugi, M., Nakamura, T., Urashima,T. and Usui, T.: Enzymatic synthesis of sulfated disaccharides using b-D-galactosidase-catalyzed transglycosylation Biosci, Biotechnol,.Biochem. 65, 2456-2464 (2001).

8) Kawagishi, H., Ysasui, M., Uno, A., Murata, T., Usui, T., and Furukawa, S.: Purification and characterization of two lectins from a toxic moray, Gymnothrax javanicus. Biosci, Biotechnol,.Biochem. 65, 2437-2442 (2001).

9) Kawagishi, H., Takagi, J., Taira, T., Murata, T., and Usui, T.: Purification and characterization of a lectin from the mushroom Mycoleptodonoides aitchisonii., Phytochemistry, 56, 53-58 (2001).

10) Kawagishi, H., Henmi, K., Oiwake, Y., Murata, T., and Usui, T.: A lectin from the shoots of Bamboo Phyllostachys pubescens. J. Appl. Glycosci., 48, 99-103 (2001).

11) Totani, K., Yasutake, N., Ohi, H., Murata, T., and Usui, T., Enzymatic synthesis of aliphatic b-lactosides as mimic units of glycosphingolipids by use of Tricoderma reesei cellulase. Arch. Biochem.Biophys., 385, 70-77 (2001).

12) Kawagishi, H., Suzuki, H., Watanabe, H., Nakamura, H., Sekiguchi, T., Murata, T., Usui, T., Sugiyama, K., Suganuma, H., Inakuma, T., Ito, K., Hashimoto, Y., Ohnishi-Kameyama, M. and Nagata, T., A lectin from an edible mushroom Pleurotus ostreatus as a food intake-suppressing substance. Biochim. Biophys. Acta, 1474, 299-308 (2000).

13) Zeng, X., Yoshino, R., Murata, T., Ajisaka, K., and Usui, T.: Regioselective synthesis of p-nitrophenyl glycosides of b-D-galactopyranosyl-disaccharide by use of transglycosylation of D-galactosidase Carbohydr. Res., 325, 120-131(2000).

14) Ashida, H., Yamamoto, K., Murata, T., Usui, T., Kumagai, H.: Characterization of endo-N-acetylgalactosaminidase from Bacillus sp. and syntheses of neo-oligosaccharides using its transglycosylation activity., Arch. Biochem.Biophys., 373, 394-400 (2000).

15) Takada, M., Ogawa, K., Murata, T. and Usui, T.: Facile enzymatic transformation of 42-O-b-D-galactosylmaltose into 42-O-b-D-galactosyl-maltobionolactone as a substrate analogue inhibitor, J. Appl. Glycosci., 47, 197-200 (2000).

16) Zeng, X., Nakaaki, Y., Murata, T. and Usui, T.: Chemo-enzymatic synthesis of glycopeptides carrying a-Neu5Ac-(2-3)-b-D-Gal-(1-3)-a-D-GalNAc, b-D-Gal-(1-3)-a-D-GalNAc, and related compounds and analysis of specific interactions with lectins, Arch. Biochem. Biophys., 382, 28-37 (2000).

17) Kawagishi, H., Suzuki, H., Watanabe, H., Nakamura, H., Sekiguchi, T., Murata, T., Usui, T., Sugiyama, K., Suganuma, H., Inakuma, T., Ito, K., Hashimoto, Y., Ohnishi-Kameyama, M. and Nagata, T.: A lectin from an edible mushroom Pleurotus ostreatus as a food intake-suppressing substance, Biochim. Biophys. Acta 1474, 299-308 (2000).

18) Murata, T. and Usui, T.: Enzymatic synthesis of important oligosaccharide units involved in N- and O-linked glycans. Tends in Glycoscience and Glycotechnology, 12, 161-174 (2000).

1999以前

1) Murata, T., Shimada, M., Watanabe, N., Sakata, K., and Usui, T.: Practical enzymatic synthesis of primeverose and its glycoside. J.Appl.Glycosci. 46, 431-437 (1999).

2) Murata, T., Morimoto, S., Watanabe, S., Zeng, X., and Usui, T.: Enzymatic synthesis of a-L-fucosyl N-acetyllactosamine and a-L-fucosyllactoses., Carbohydr. Res., 320, 192-199 (1999).

3) Murata, T., Inukai, T., Suzuki, M., and Usui, T.: Facile enzymatic conversion of lactose into lacto-N-tetraose and lacto-N-neotetraose., Glycoconjugate J., 16, 185-195 (1999).

4) Zeng, X., Morimoto, S., Murata, T., and Usui, T.: Regioselsctivity of a-L-fucosyloligosaccharide formation by the a-L-fucosidase from porcine liver. J.Appl.Glycosci. 46, 241-247 (1999).

5) Takada, M., Ogawa, K., Saito, S., Murata, T., and Usui, T.: Chemo-enzymatic synthesis of 63-O-benzyl and 63-O-b-D-galactosylmaltotrionolactones as inhibitors for human a-amylases. J. Carbohydr. Chem. 18, 149-163 (1999).

6) Zeng, X., Murata, T., Kawagishi, H., Usui, T. and Kobayashi, K., Synthesis of artificial N-glycopolypeptides carrying N-acetyllactosamine and related compounds and their specific interactions with lectins. Biosci. Biotechnol. Biochem., 62(6), 1171-1178 (1998).

7) Zeng, X., Murata, T., Kawagishi, H., Usui, T. and Kobayashi, K., Analysis of specific interactions of synthetic glycopolypeptides carrying N-acetyllactosamine and related compounds with lectins. Carbohydr. Res., 312, 209-217 (1998).

8) Zeng, X., Murata, T., Kawagishi H., Usui, T., and Kobayashi, K.: Analysis of specific interactions of synthetic glycopolypeptides carrying N-acetyllactosamine and related compounds with lectins. Carbohydr. Res. 312, 209-217 (1998).

9) Murata, T., Itoh, T., and Usui, T. Enzymatic synthesis of b-D-Gal-(1→3)-[b-D-GlcNAc-(1→6)]-a-D-GalNAc-OC6H4NO2-p as a carbohydrate unit of mucin-type 2 core., Glycoconjugate J., 15, 575-582 (1998).

10) Zeng, X., Murata, T., Kawagishi, H., Usui, T. and Kobayashi, K.: Synthesis of artificial N-glycopolypeptides carrying N-acetyllactosamine and related compounds and their specific interactions with lectins., Biosci. Biotech. Biochem., 62, 1171-1178 (1998).

11) Takada, M, Ogawa, K., Saito, S., Murata, T., and Usui, T.: Chemo-enzymatic synthesis of galactosylmaltooligonolactone as substrate analogue inhibitor for mammalian a-amylase., J. Biochem., 123, 508-515 (1998).

12) Kobayashi, K., Kamiya, S., Matsuyama, M., Murata, T. and Usui, T.: Synthesis and function of a glycopolymer carrying Galb1-4(GlcNAc)3 tetrasaccharide., Polymer J. 30, 653-658 (1998).

13) Usui, T., and Murata, T.: Enzymatic synthesis of p-nitrophenyl a-maltopentaoside in an aqueous-methanol solvent system by maltotetraose-forming amylase. A substrate for human amylase in serum. J. Biochem. 103, 969-972 (1988).

14) Murata, T., Tanuma, S., Ikekita, M. et al.: Structural alteration of cell surface oligosaccharides on HL-60RG cells undergoing apoptosis, Res. Commn. Biochem. Cell Mol. Biol. 1, 249-262 (1997).

15) Murata, T.,　Shibatsuji,　M., Hara, H., Yasuno, S., Yamaguchi, T., Kizuki, K., Hoshino, O., Tanuma, S., Moriya, H., Sweeley, C.C., and Ikekita, M.: Structural characterization of sialylated and neutral N-linked oligosaccharides labeled with p-aminobenzoic acid octyl ester by high performance liquid chromatography and fast atom bombardment mass spectrometry, Res. Commn. Biochem. Cell Mol. Biol. 1, 285-303 (1997).

16) Yasuno, S, Murata, T., Kokubo, K. Kamei, M.: Two-mode analysis by high-performance liquid chromatography of p-aminobenzoic ethyl ester-derivatized monosaccharides, Biosci. Biotech. Biochem. 61, 1944-1946 (1997).

17) Murata, T., Tashiro, A., Itoh, T., Usui, T.: Enzymic synthesis of 3'-O- and 6'-O-N-acetylglucosaminyl-N-acetyllactosaminide glycosides catalyzed by b-N-acetyl-D-hexosaminidase from Nocardia orientalis, Biochim. Biophys. Acta 1335, 326-334 (1997).

18) Murata, T., Akimoto S., Horimoto, M., and Usui, T.: Galactosyl transfer onto p-nitrophenyl b-D-glucoside using the b-D-galactosidase from Bacillus circulans, Biosci Biotech Biochem 61, 1118-1120 (1997).

19) Kawagishi, H., Mitsunaga, S.-I., Yamawaki, M., Ido, M., Shimada, A., Kinoshita, T., Murata, T., Usui, T., Kimura, A., and Chiba, S.: A lectin from the mycelia of a fungus Ganoderma lucidum., Phytochemistry, 44, 7-10 (1997).

20) Ikekita, M., Yajima, H., Murata, T., Takatera, T., Watanabe, T., Sonoyama, M., Tezuka, Y., Ishii, T., and Tarutani, O.: Carbohydrate analysis of porcine thyroglobulin isoformes with different iodine contents. Biochim. Biophys. Acta 1336, 557-565 (1997).

21) Murata, T, Usui T.: Preparation of oligosaccharide units library and its utilization, Biosci. Biotech. Biochem. 61: 1059-1066 (1997).

3) Kawagishi, H., Wasa, T., Murata, T., Usui, T., Kimura, A. and Chiba, S., Two N-acetyl-D-galactosamine-specific lectins from Phaeolepiota aurea. Phytochemistry, 41(4), 1013-1016 (1996).

22) Murata, T., Itoh, T., Hayakawa, Y., and Usui, T., Convenient synthesis of b-(1→3)-galactosyl disaccharide a-glycoside and its analogs as mimic units of mucin-type carbohydrate. J. Biochem. 120, 851-855 (1996).

23) Usui, T., Morimoto, S., Hayakawa, Y., Kawaguchi, M., Murata, T., Matahira, Y., and Nishida, Y.: Regioselectivity of b-D-galactosyl-disaccharide formation using the b-D-galactosidase from Bacillus circulans, Carbohydr. Rea., 285, 29-39 (1996).

24) Zhuang, C., Murata, T., Usui, T., Kawagishi, H., and Kobayashi K.: Purification and characterization of a lectin from the toxic mushroom Amanita pantherina, Biochim. Biophys. Acta 1291, 40-44 (1996).

25) Kawagishi, H., Wasa, T., Murata, T., Usui, T., Kimura, A., and Chiba, S.: Two N-acetyl-D-galactosamine-specific lectins from Phaeolepiota aurea, Phytochemistry 41, 1013-1016 (1996).

26) Usui, T., Murata, T., Yabuucti, Y., and Ogawa, K.: Transglycosylation reaction of maltotriose-forming amylase from Streptomyces griseus. Carbohydr. Res., 250, 57-66 (1993).

27) Kawashima, H., Murata, T., Yamamoto, K., Tateishi, A., Irimura, T., and Osawa, T.: A simple method for the release of asparagine-linked oligosaccharides from a glycoprotein purified by SDS-polyacrylamide gel electrophoresis. J. Biochem. 111, 620-622 (1992).

28) Ogawa, K., Murata, T., and Usui, T.: Maltotetraose-foming, amylase mediated, p-nitrophenyl a- and b-maltopentaoside formation in an aqueous-organic solvent system: a substrate for human amylase in serum. Carbohydr. Res. 212, 289-294 (1991).

29) Usui, T., and Murata, T.: Enzymatic synthesis of p-nitrophenyl a-maltopentaoside in an aqueous-methanol solvent system by maltotetraose-forming amylase. A substrate for human amylase in serum. J. Biochem. 103, 969-972 (1988).

2. 著書

1) 村田健臣: 戦略的創造研究事業(CREST)糖鎖の生物機能の解明と利用技術、「担癌状態におけるムチンを介した免疫能の変化の解析と応用」研究終了報告，科学技術振興機構，p32-37. (2009).

2) Murata T., and Uusi T: Convenient synthesis of glycan-related oligosaccharides and their transformation into neoglycoconjugates using enzymatic methods. Experimental Glycoscience, Glycobiology, Part 1 Glycosyltranseferase gene, Section 1 Glycosyltransferase, 5-8, Springer (2008).

3.) 村田健臣，碓氷泰市：糖鎖科学の最先端技術「グリコシダーゼを中心とした重要オリゴ糖鎖単位の酵素合成」，小林一清、正田晋一郎（編），シーエムシー出版，p.21-30 (2005).

4) 村田健臣，碓氷泰市：未来を拓く糖鎖科学「酵素法を組み合わせた生活性オリゴ糖鎖分子の合成、永井克孝（監修）金芳堂、p.130-132,(2005).

5) 碓氷泰市，村田健臣：糖鎖科学の新展開「分子認識チップとしてのオリゴ糖鎖の合成と展開」, 谷口直之、伊藤幸成（編），エヌティーエス出版，p.510-517(2005).

6) 村田 健臣: 日本農芸化学会奨励賞招待講演，「糖鎖ライブラリーを利用した分子認識プローブの構築に関する研究」，日本農芸化学会2005年度大会（札幌）講演要旨集，p.368-369 (2005).

7) 村田健臣: 日本農芸化学会奨励賞招待講演，「糖鎖ライブラリーを利用した分子認識プローブの構築に関する研究」, 2005年日本農芸化学会中部支部例会（静岡）講演要旨集，p. 3. (2005).

8) 村田健臣，餘目　哲，碓氷泰市，大嶋秀克，虻川久美子，神崎文次，細野明義：オリゴ糖酸化酵素を利用した生乳中ラクトースの定量，日本農芸化学会誌，75，447-449，(2001).

9) 村田健臣，碓氷泰市：機能性オリゴ糖鎖の構築，日本農芸化学会誌，75，576-579，(2001).

10) 村田健臣：新しいバイオシグナル素子－オリゴ糖鎖の構築，生物工学会誌，79，115，(2001).

11) 碓氷泰市・村田健臣：エキソグリコシダーゼを中心としたオリゴ糖鎖の実践的合成，季刊化学総説，糖鎖分子の設計と生理機能，日本化学会編，学会出版センター，48，17-23, (2001).

12) 村田健臣：ヒト型ミルクオリゴ糖鎖の大量合成とその応用に関する研究，日本農芸化学会誌，74，688-700, (2000).

13) 村田健臣，碓氷泰市：酵素法によるオリゴ糖鎖ライブラリーの構築， J.Appl.Glycosci., 47, 253-260 (2000).

14) 村田健臣，碓氷泰市：ヒトミルクオリゴ糖の合成戦略，ﾐﾙｸｻｲｴﾝｽ，48，207-211(1999).

15) 村田健臣・丸田英晴：糖タンパク質糖鎖の解析，細胞表面糖鎖の解析（分担執筆），細胞工学別冊アポトーシス実験プロトコール2応用編（秀潤社）田沼靖一監修，p.35-42，p.56-59（1998）

16) 高田正保，小川浩一，斉藤三四郎，村田健臣，碓氷泰市：酵素変換によるα-アミラーゼ阻害剤の分子設計, 応用糖質科学, 44 (2), 213-221 (1997).

17) 碓氷泰市, 村田健臣：オリゴ糖鎖ライブラリーの作製, 有機合成化学協会誌, 54, 607-615 (1996)

3. 特許

1) 特開2008-031156 抗ウルス剤、　国立大学法人静岡大学、静岡県、ヤマサ醤油（株）、村田健臣, 左一八、碓氷泰市、鈴木隆、鈴木康夫、武田聡、山田浩平、野口利忠、

2) 特開2008-301792 改変ポリへドリンプロモーター、バクミド変異体及び目的タンパク質の製造方法、国立大学法人静岡大学、朴龍洙、金政真、碓氷泰市、村田健臣

3) 米国出願12/666482(PCT/JP2008/061429関連)、新規なＮ結合型人工シアロ糖鎖含有ポリマーおよびその製造方法、国立大学法人静岡大学、静岡県、ヤマサ醤油（株）、鈴木隆、左 一八、村田健臣、碓氷泰市、大庭勇介、浜本智樹、野口利忠 4) WO2007-026669 ウイルスレセプター糖鎖認識特異性の判別、静岡県公立大学法人、国立大学法人静岡大学、ヤマサ醤油（株）、鈴木康夫、浅井章良、鈴木隆、左一八、村田健臣、碓氷泰市、武田聡、山田浩平、野口利忠

5) 特開2007-246421　ヒアルロン酸産生促進剤、国立大学法人静岡大学、天野エンザイム（株）、（株）クラレ、碓氷泰市、村田健臣、森　茂治、塩野万蔵

6) 特開2006-241095　フィラグリン合成促進剤および紫外線障害緩和剤、国立大学法人静岡大学、天野エンザイム（株）、日本食品加工（株）、碓氷泰市、村田健臣、高田正保、小川浩一、森　茂治

7) 特開2006-062982　免疫抑制剤, 学校法人 京都産業大学、国立大学法人静岡大学、中田博、碓氷泰市、村田健臣

8) 特開2006-232779　双頭型配糖体及びその製造法、焼津水産化学工業（株）、国立大学法人静岡大学、碓氷泰市、村田健臣、又平芳春、三澤義知

9) 特開2004-25647　糖脂質の製造方法、日本食品加工（株）、天野エンザイム（株）、碓氷泰市、村田健臣、戸谷一英

10) 特開2004-254562 ポリ-N-アセチルラクトサミン誘導体の製造方法、焼津水産化学工業（株）、碓氷泰市，村田健臣、服部武史、西宮可織、神保詩織

11) 特開2003-073397 合成ムチン、わかもと製薬（株）、碓氷泰市，小林一清、鈴木康夫、村田健臣，戸谷一英

12) WO2003-072795　グリコシダーゼを用いた配糖体の製造方法、天野エンザイム（株）、日本食品加工（株）、碓氷泰市，村田健臣、山本幹男、高田正保、森　茂治、鶴喰寿孝

13) WO2001-014575　配糖体の製造方法、昭和産業（株）、安武望，三吉新介、碓氷泰市、村田健臣、戸谷一英．

14) 特開2001-019698　硫酸化オリゴ糖化合物およびその合成、科学技術振興事業団、村田健臣、碓氷泰市

15) 特開平10-80587　ラクト-N-テトラオースの合成法、明治製菓（株）、碓氷泰市，村田健臣，鰺坂勝美、山本裕一

16) 特開平10-234394　ラクト-N-ネオテトラオースの製造法、ヤマサ醤油（株）、碓氷泰市，村田健臣

17) 特開平９-234094　糖または誘導体の製造方法、明治製菓（株）、碓氷泰市，村田健臣

18) 特開平3-227999 糖タンパク質からの糖鎖の切り出し法、（株）ホーネンコーポレーション、（財）杉山産業化学研究所、亀井麻直、村田健臣，山口隆司、後藤勝、小山史裕

19) 特開平3-22800 糖タンパク質からの糖鎖の切り出し法、（株）ホーネンコーポレーション、（財）杉山産業化学研究所、亀井麻直、村田健臣，山口隆司、後藤勝、小山史裕