J. Antibiotic. 73, 733-736 (2020)
Axl and immune checkpoints inhibitors from the fruiting bodies of Pleurocybella porrigens
Ridwan, Y. A., Wu, J., Harada, E., D’Alessandro-Gabazza, C., Toda, M., Yasuma,T., Gabazza, E. C., Choi, J-H., Hirai, H., and Kawagishi, H.
A novel compound (1) and three known ones (2−4) were isolated from the fruiting bodies of Pleurocybella porrigens. The structure of the novel compound was determined by 1D and 2D NMR and HRESIMS data. The biological activity of 1−3 was evaluated using the A549 lung cancer cell line. The results showed the inhibitory activity of compounds 1−3 on the expression of Axl and immune checkpoint molecules.