Biosci. Biotechnol. Biochem. 87 , 420–425 (2023)
The role of xanthine dioxygenase in the biosynthetic pathway of 2-aza-8-oxohypoxanthine of Lepista sordida
Kotajima, M., Choi, J-H., Suzuki, T., Wu, J., Hirai, H., Nelson, D. C., Ouchi, H., Inai, M., Dohra, H., and Kawagishi, H.
2-Azahypoxanthine (AHX) and 2-aza-8-oxohypoxanthine (AOH), discovered as causal substances of fairy rings are known to be endogenous in the fairy ring-forming Lepista sordida. In this study, we showed that xanthine dioxygenase, an a-ketoglutarate-dependent dioxygenase, might catalyze the conversion of AHX to AOH in the fungus. Furthermore, this enzyme is the first reported molybdopterin-independent protein of hypoxanthine metabolism.